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Antioxidant vitamins attenuate oxidative stress and cardiac dysfunction in tachycardia-induced cardiomyopathy

Junya Shite, MD^*, Fuzhong Qin, MD, PhD^*, Weike Mao, MD^*, Hiroya Kawai, MD^*, Suzanne Y. Stevens, PhD and Chang-seng Liang, MD, PhD, FACC^*,*

^* Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York, USA

View larger version (30K): [in a new window]   Figure 1 Serial changes in left ventricular end-diastolic dimension and fractional shortening in animals with congestive heart failure (CHF) and sham-operated animals. The changes in sham-operated animals treated with antioxidant vitamins were the same as in placebo-treated sham animals. Bars = SEM. *p < 0.05 vs. the sham animals; p < 0.05 vs. the CHF + placebo group; p < 0.05 vs. the CHF + vitamins group. The number of animals in each group is shown in Table 1.

View larger version (58K): [in a new window]   Figure 2 Change in left ventricular (LV) peak positive first derivative of LV pressure (dP/dt) in response to isoproterenol administration and myocardial beta-receptor density in sham animals and animals with congestive heart failure (CHF). Symbols as in Figure 1.

View larger version (44K): [in a new window]   Figure 3 Changes in myocardial reduced glutathione/oxidized glutathione (GSH/GSSG) and mitochondrial DNA (mtDNA) 8-oxo-7,8-dihydro-2'-deoxyguanosine/2'-deoxyguanosine (8-oxo-dG/dG) ratios in sham animals and animals with CHF. Symbols as in Figure 1.

View larger version (49K): [in a new window]   Figure 4 Changes in left ventricular norepinephrine (NE) uptake-1 carrier site density, catecholaminergic fluorescence profile and tyrosine hydroxylase immunostained profile in sham animals and in animals with congestive heart failure (CHF). Symbols as in Figure 1.