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Life-threatening ventricular arrhythmias due to transient or correctable causes: high risk for death in follow-up

D. George Wyse, MD, PhD, FACC^*,*, Peter L. Friedman, MD, FACC, Michael A. Brodsky, MD, FACC, Karen J. Beckman, MD, FACC, Mark D. Carlson, MD, FACC^||, Anne B. Curtis, MD, FACC^¶, Alfred P. Hallstrom, PhD^#, Merritt H. Raitt, MD, FACC^**, Bruce L. Wilkoff, MD, FACC, H. Leon Greene, MD, FACC^# for the AVID Investigators

^* Cardiology Division, University of Calgary, Calgary, Alberta, Canada
Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Cardiology Division, University of California at Irvine, Irvine, California, USA
Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
^|| Cardiology Division, Case Western Reserve University, Cleveland, Ohio, USA
^¶ Cardiovascular Division, University of Florida, Gainesville, Florida, USA
^# Department of Biostatistics, University of Washington, Seattle, Washington, USA
^** Division of Cardiology, Oregon Health Sciences University, Portland, Oregon, USA
Cardiology Division, the Cleveland Clinic Foundation, Cleveland, Ohio, USA

View larger version (18K): [in a new window]   Figure 1 Survival curves comparing patients with high-risk ventricular tachycardia/ventricular fibrillation (Primary VT/VF) versus a transient/correctable cause for the VT/VF (Transient VT/VF). Upper panel shows unadjusted data (p = NS), and the lower panel depicts results after adjustment for five variables known to affect mortality (p = 0.008, see text).

View larger version (19K): [in a new window]   Figure 2 Survival curves for six subgroups of patients with a transient/correctable cause for their presenting ventricular tachycardia/fibrillation. The subgroups are those listed in Table 2: non–Q-wave myocardial infarction (MI) (n = 83), Q-wave MI (n = 78) and ischemia-no MI (n = 22) in the upper panel. (Lower panel) Electrolyte imbalance (n = 27), antiarrhythmic drug (AAD) reaction (n = 18) and other or unknown (n = 50). P = NS.