Cardiovascular effects of carbon monoxide and cigarette smoking
Shoshana Zevin, MD*,
Sandra Saunders, MD
,
Steven G. Gourlay, MBBS, PhD 
,
Peyton Jacob, III, PhD and
Neal L. Benowitz, MD*,
* Department of Internal Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and the Departments of Medicine, Psychiatry and Biopharmaceutical Sciences, University of California, San Francisco, San Francisco, California, USA
Pharmacological Sciences, Genentech Inc., South San Francisco, California, USA
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Figure 1 Mean (± SEM) carboxyhemoglobin (COHb) time course on day 5 of carbon monoxide inhalations (CO), cigarette smoking (CS) and air inhalations (AIR). Smoking and inhalation treatments started at 8 AM and were administered every 40 min till midnight.
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Figure 2 Mean (± SEM) urinary levels of epinephrine, norepinephrine, and dopamine on carbon monoxide inhalations (CO), cigarette smoking (CS) and air inhalations (AIR), n = 10. *p < 0.05. Urine was collected for 24 h. The levels while smoking cigarettes were significantly (p < 0.05) higher compared to other treatments.
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Figure 3 Mean (± SEM) plasma levels of C-reactive protein (CRP) on carbon monoxide inhalations (CO), cigarette smoking (CS) and air inhalations (AIR). Analysis of variance of log CRP revealed a significant effect of cigarette smoking (*p < 0.005). Differences were significant both at 8 AM and 12 PM.
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Copyright © 2001 by the American College of Cardiology Foundation.
