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Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy

Takayoshi Tsutamoto, MD^*,*, Atsuyuki Wada, MD^*, Keiko Maeda, MD^*, Naoko Mabuchi, MD^*, Masaru Hayashi, MD^*, Takashi Tsutsui, MD^*, Masato Ohnishi, MD^*, Masanori Fujii, MD^*, Takehiro Matsumoto, MD^*, Takashi Yamamoto, MD^*, Xinwen Wang, MD^*, Shigeru Asai, PhD, Tetsuo Tsuji, PhD, Hitoshi Tanaka, PhD, Yoshihiko Saito, MD, Koichiro Kuwahara, MD, Kazuwa Nakao, MD and Masahiko Kinoshita, MD^*

^* First Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan
Diagnostic Department, Shionogi & Co., Osaka, Japan
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan

View larger version (19K): [in a new window]   Figure 1 Plasma cardiotrophin-1 (CT-1) concentrations in control subjects and in congestive heart failure (CHF) patients with dilated cardiomyopathy. Mild CHF = New York Heart Association (NYHA) functional class II; severe CHF = NYHA functional class III–IV. *p < 0.05 versus the value of control subjects; #p < 0.05 versus the value of the mild CHF.

View larger version (16K): [in a new window]   Figure 2 Plasma cardiotrophin-1 (CT-1) concentrations in patients with dilated cardiomyopathy. Patients were classified into two groups: small left ventricular mass index (LVMI) group and large LVMI, based on the median value of LV mass index. *p < 0.01 versus the value in the small LVMI group.

View larger version (21K): [in a new window]   Figure 3 Correlation between the plasma cardiotrophin-1 (CT-1) concentrations and the left ventricular (LV) mass index in patients with dilated cardiomyopathy.