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Predictors of coronary in-stent restenosis: importance of angiotensin-converting enzyme gene polymorphism and treatment with angiotensin-converting enzyme inhibitors

Erik Jørgensen, MD^*,*, Henning Kelbæk, MD^*, Steffen Helqvist, MD^*, Gunnar V. H. Jensen, MD^*, Kari Saunamäki, MD^*, Jens Kastrup, MD^*, Ole Havndrup, MD^*, Henning Bundgaard, MD^*, Jan Kyst Madsen, MD^*, Michael Christiansen, MD, Paal S. Andersen, PhD and Johan H. C. Reiber, PhD

^* Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen, Denmark
the Department of Clinical Biochemistry, Statens Serum Institute, Copenhagen, Denmark
Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

View larger version (24K): [in a new window]   Figure 1 The cumulative distribution curve of minimal lumen diameter in 369 patients before stent implantation (curves at the left), after stent implantation (curves at the right) and at follow-up (curves in the middle). DD = homozygotes with two deletion alleles in the angiotensin-converting enzyme (ACE) gene; DI = heterozygotes with one deletion and one insertion allele in the ACE gene; II = homozygotes with two insertion alleles in the ACE gene.