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Potentiation of bradykinin-induced tissue plasminogen activator release by angiotensin-converting enzyme inhibition

Catherine Labinjoh, BSc, MB, ChB (Hons), MRCP^*, David E. Newby, BA, BSc, PhD, DM, (Hons), BM, MRCP^*,* , M. Paola Pellegrini, MB, ChB^*, Neil R. Johnston, MSc^*, Nicholas A. Boon, BA, MB, MA, MD, BChir, FRCP and David J. Webb, MB, MD, DSc, FRCP, FFPM, FMedSci^*

^* Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, United Kingdom
Department of Cardiology, Royal Infirmary, Lauriston Place, Edinburgh, United Kingdom

View larger version (11K): [in a new window]   Figure 1 Infused forearm blood flow response to intrabrachial infusion of substance P, sodium nitroprusside and bradykinin during placebo (open circles), quinapril (closed circles) and losartan (closed squares) administration. p < 0.001 (analysis of variance) for all blood flow responses.

View larger version (18K): [in a new window]   Figure 2 Forearm concentration difference (left) and estimated net release (right) of tissue plasminogen activator (t-PA) antigen (upper, solid lines) and activity (lower, dashed lines) in response to intrabrachial infusion of bradykinin during placebo (open circles), quinapril (closed circles) and losartan (closed squares) administration. p < 0.001 (analysis of variance, ANOVA) for all responses. *p = 0.003, p = 0.03, p = 0.09, p = 0.13 two-way ANOVA: quinapril versus losartan and placebo (p < 0.001 for t-PA response and p = ns for interaction).