Relationship between transcardiac extraction of aldosterone and left ventricular remodeling in patients with first acute myocardial infarction: extracting aldosterone through the heart promotes ventricular remodeling after acute myocardial infarction
Masaru Hayashi, MDa,
Takayoshi Tsutamoto, MD*,a,
Atsuyuki Wada, MDa,
Keiko Maeda, MDa,
Naoko Mabuchi, MDa,
Takashi Tsutsui, MDa,
Toshiki Matsui, MDa,
Masanori Fujii, MDa,
Takehiro Matsumoto, MDa,
Takashi Yamamoto, MDa,
Hajime Horie, MDa,
Masato Ohnishi, MDa and
Masahiko Kinoshita, MDa
a First Department of Internal Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Japan
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Figure 1 Plasma aldosterone (ALD) concentrations at the acute phase in the aortic root (Ao) and coronary sinus (CS) in patients with acute myocardial infarction (AMI). (Left) ALD data in all 57 patients with AMI; (Middle) ALD data in 28 patients in the high-extraction group; (Right) ALD data in 29 patients in the low-extraction group.
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Figure 2 (Left) The correlation between the transcardiac gradient of aldosterone (ALD) at the acute phase and the left ventricular end-diastolic volume index (LVEDVI) one month after onset in patients with acute myocardial infarction. (Right) The correlation between the transcardiac gradient of ALD at the acute phase and the difference in LVEDVI between one month and the acute phase (absolute change). Ao = aortic root; CS = coronary sinus.
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Figure 3 Correlation between the plasma levels of procollagen type III aminoterminal peptide (PIIINP) one month after onset and the transcardiac gradient of aldosterone (ALD) at the acute phase (left) and left ventricular end-diastolic volume index (LVEDVI) after one month in patients with acute myocardial infarction (right). Ao = aortic root; CS = coronary sinus.
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Figure 4 (Left) The correlation between the plasma level of aldosterone (ALD) in the aortic root (Ao) at the acute phase and the transcardiac gradient of plasma ALD at the acute phase in a patient with acute myocardial infarction (AMI). (Right) The correlation between the transcardiac gradient of ALD at the acute phase and one month after onset in patients with AMI. CS = coronary sinus.
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