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Increased intimal apoptosis in coronary atherosclerotic vessel segments lacking compensatory enlargement

^a Department of Cardiology, University of Vienna, Vienna, Austria
^b Department of Pathology, University of Vienna, Vienna, Austria

View larger version (16K): [in a new window]   Figure 1 Apoptotic indices (APO) (A) and proliferating cell nuclear antigen (PCNA)-positive nuclei per 100 counted nuclei (B) are plotted on the y-axis, in relation to the three categories (CAT) of vascular remodeling on the x-axis. The analysis of APO reached statistical significance.

View larger version (119K): [in a new window]   Figure 2 Histology and immunohistology of representative examples of coronary atherectomy specimens. (a, c, e, g, i) Typical example of a R– specimen. (a) A modified trichrome stain with erythrocytes staining yellow; fibrin stains red, collagen stains green and elastic fibers stain dark blue. The internal elastic lamina was utilized as the landmark for identifying the intimal-medial interface. (c) A parallel section where red nuclear staining represents a positive TUNEL reaction. (e) Immunoreactivity with anti-proliferating cell nuclear antigen (PCNA). Note few positive nuclei. (b, d, f, h, j) Typical example of a R+ specimen. (b) A modified trichrome stain. Note that in this case the internal elastic lamina is present, because directional coronary atherectomy cut has also removed deeper parts of the arterial wall. Parts of the medial layer are shown at the bottom of the photomicrograph. (d) A parallel section where red nuclear immunoreactivity represents positive TUNEL reaction. (f) Anti-PCNA immunoreactivity. The areas highlighted by rectangles are shown in g, h, i and j at a higher magnification. The scale bars represent 10 µm.

View larger version (113K): [in a new window]   Figure 3 Modified trichrome stain of a representative R– atherectomy specimen. Green layers of collagen alternate with layers of cell-rich tissue, suggesting recurrent episodes of plaque rupture and healing.