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Reduced kidney function and anemia as risk factors for mortality in patients with left ventricular dysfunction

Amin Al-Ahmad, MD^*, William M. Rand, PhD, Guruprasad Manjunath, MD, Marvin A. Konstam, MD^*, Deeb N. Salem, MD^*, Andrew S. Levey, MD and Mark J. Sarnak, MD

^* Division of Cardiology, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
Department of Community Health, Tufts University School of Medicine, Boston, Massachusetts, USA
Division of Nephrology, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

View larger version (16K): [in a new window]   Figure 1 (A) Distribution of glomerular filtration rate (GFR) in the Study Of Left Ventricular Dysfunction (SOLVD). Mean is 70 ml/min/1.73 m2, with a standard deviation of 19.3 and n is 6,630. A total of 6.8% of patients had a GFR of <45 ml/min/1.73 m2, 25% between 45 ml/min/1.73 m2 to 60 ml/min/1.73 m2, 32.1% between 60 to 75 ml/min/1.73 m2, 21.7% between 75 to 90 ml/min/1.73 m2 and 14.4% >90 ml/min/1.73 m2. (B) Distribution of hematocrit in SOLVD. Mean is 43; SD is 4.49 and n is 6,563. A total of 4.3% of the patients have a hematocrit <35%, 17.5% between 35 and 39, 51.7% between 40 and 45, 23.1% between 45 and 50 and 3.3% > 50.

View larger version (16K): [in a new window]   Figure 2 Kaplan-Meier survival analysis by level of glomerular filtration rate (GFR).

View larger version (18K): [in a new window]   Figure 3 (A) Kaplan-Meier survival analysis by level of hematocrit (Hct) in men. (B) Kaplan Meier survival analysis by level of Hct in women.