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Prospective crossover comparison of carvedilol and metoprolol in patients with chronic heart failure

Christoph Maack, MD^*, Thomas Elter, MD, Georg Nickenig, MD^*, Karl LaRosee, MD, Marina Crivaro, MD, Alexander Stäblein, MD, Henrike Wuttke, MD and Michael Böhm, MD^*

^* Medizinische Klinik und Poliklinik, Innere Medizin III, Universitätskliniken des Saarlandes, Homburg, Germany
Klinik III für Innere Medizin, Universität zu Köln; Köln, Germany
Institut für Experimentelle und Klinische Pharmakologie und Toxikologie; Friedrich-Alexander Universität; Erlangen, Germany

View larger version (27K): [in a new window]   Figure 1 Study flow chart. DSE = dobutamine stress echocardiography.

View larger version (23K): [in a new window]   Figure 2 Effects of maximum dose of dobutamine (40 µg/kg per min) on heart rate (HR) (A), end-diastolic diameter (EDD) (B), left ventricular ejection fraction (LVEF) (C), stroke volume (SV) (D) and cardiac output (C.O.) (E). Values are given as the relative increase or decrease from baseline values, respectively.