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Attenuation of angiotensin II-mediated coronary vasoconstriction and vasodilatory action of angiotensin-converting enzyme inhibitor in pacing-induced heart failure in dogs

^a First Department of Internal Medicine, Fukushima Medical University, Fukushima, Japan

View larger version (23K): [in a new window]   Figure 1 Changes in coronary blood flow caused by administration of angiotensin II (Ang II) at perfusion pressures of 40, 50 and 60 mm Hg (mean values ± SEM). See text for details. a, Baseline (n = 11). b, After rapid pacing for three weeks (3W, n = 11). c, After rapid pacing for five weeks (5W, n = 5). Control indicates before administration of angiotensin II; Ang II indicates after administration of angiotensin II; LV = left ventricular mass.

View larger version (20K): [in a new window]   Figure 2 Changes in coronary blood flow caused by enalaprilat at perfusion pressures of 30, 40, 50 and 60 mm Hg (mean values ± SEM). a, Baseline (n = 11). b, After rapid pacing for three weeks (3W, n = 11). c, After rapid pacing for five weeks (5W, n = 5). After three weeks of rapid pacing, enalaprilat significantly increased coronary blood flow at all perfusion pressures, whereas the increase was attenuated, but still significant, after five weeks of rapid pacing. Control indicates before administration of enalaprilat; enalaprilat indicates after administration of enalaprilat; LV = left ventricular mass.