Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension
Response to iloprost inhalation
Ralph Wiedemann, MDa,
H. Ardeschir Ghofrani, MDa,
Norbert Weissmann, PhDa,
Ralph Schermuly, PhDa,
Karin Quanz, MDa,
Friedrich Grimminger, MD, PhDa,
Werner Seeger, MDa and
Horst Olschewski, MD, FESCa
a Department of Internal Medicine II, Justus-Liebig-University, Giessen, Germany
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Figure 1 Correlation of atrial natriuretic peptide (ANP) with baseline hemodynamic parameters. Open circles = patients with PPH; closed circles = patients with NPPH. Atrial natriuretic peptide levels were from pulmonary artery samples. cGMP = pulmonary artery cyclic guanylate monophosphate concentration; CI = cardiac index; mPAP = mean pulmonary arterial pressure; mSAP = mean systemic arterial pressure; PVR = pulmonary vascular resistance; RAP = right atrial pressure; RVEF = right ventricular ejection fraction; SvO2 = central venous oxygen saturation.
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Figure 2 Correlation of atrial natriuretic peptide (ANP) changes with the hemodynamic changes in response to iloprost inhalation. Open circles = patients with PPH; closed circles = patients with NPPH. Atrial natriuretic peptide levels were from pulmonary artery samples. Abbreviations as in Figure 1.
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