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Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation: a human in vivo study

Ursula Jurt, MD^* , Tommaso Gori, MD^* , Amir Ravandi, PhD, Saeid Babaei, MSc, Peter Zeman^* and John D. Parker, MD, FACC^*

^* Division of Cardiology, Department of Medicine, Mount Sinai Hospital, Toronto, Canada
University Health Network, Toronto, Canada
Cardiovascular Collaborative Program, Toronto, Canada
Department of Laboratory Medicine and Pathobiology, Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada

View larger version (13K): [in a new window]   Figure 1 Percent change in forearm blood volume in response to 0.6 mg sublingual nitroglycerin (GTN) in the three groups. *p < 0.05 compared with GTN group, analysis of covariance. p < 0.05 compared with before randomization, paired t test; p = NS before randomization versus after chronic administration for control and pentaerythritol tetranitrate (PETN) groups, paired t test. Open bar = before randomization; closed bar = after chronic administration.

View larger version (19K): [in a new window]   Figure 2 Cytotoxic aldehydes (total of the four compounds measured) after continuous treatment in the three groups. *p < 0.02 compared with control and pentaerythritol tetranitrate (PETN), analysis of variance. GTN = nitroglycerin.

View larger version (17K): [in a new window]   Figure 3 Isoprostanes (total of the three compounds measured) after continuous treatment. *p < 0.005 compared with control and pentaerythritol tetranitrate (PETN), analysis of variance. GTN = nitroglycerin.