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Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease?

Insights from a population-based study

Yoram Agmon, MD^*,1, Bijoy K. Khandheria, MD, FACC^*, Irene Meissner, MD, JoRean D. Sicks, MS, W. Michael O’Fallon, PhD, David O. Wiebers, MD, Jack P. Whisnant, MD, James B. Seward, MD, FACC^* and A. Jamil Tajik, MD, FACC^*

^* Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA
Department of Health Science Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

View larger version (89K): [in a new window]   Figure 1 Transesophageal echocardiographic examples of normal (A) and sclerotic (B) aortic valves. Note the irregular thickening of the sclerotic aortic valve leaflets. Ao = aorta; LVOT = left ventricular outflow tract.

View larger version (20K): [in a new window]   Figure 2 Probability of aortic valve sclerosis by age and gender. Note the nonlinear relationship with age and the interaction between age and gender. There is approximately a decade difference between men and women in the age-associated increasing frequency of aortic valve sclerosis (earlier in men). The marks at the top and the bottom of the figure indicate individuals with and without aortic sclerosis, respectively.

View larger version (19K): [in a new window]   Figure 3 Probability of upper quintile transaortic velocities by age and gender. The marks at the top and the bottom of the figure indicate individuals with and without upper quintile velocities, respectively.