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Simvastatin treatment is associated with improvement in coronary endothelial function and decreased cytokine activation in patients after heart transplantation

Michael Weis, MD^*, Sinan Pehlivanli, MD, Bruno M. Meiser, MD and Wolfgang von Scheidt, MD

^* Stanford University Medical School, Falk Cardiovascular Research Center, Stanford, California, USA
Division of Cardiology, University Hospital Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany
Division of Cardiovascular Surgery, University Hospital Grosshadern, Ludwig-Maximilians University of Munich, Munich, Germany

View larger version (14K): [in a new window]   Figure 1 Epicardial endothelium-dependent vasomotor response. Epicardial diameter change in response to intracoronary acetylcholine (ACh). Group 1 = patients with hypercholesterolemia adequately controlled; group 2 = patients with hypercholesterolemia inadequately controlled; group 3 = patients without hypercholesterolemia. *p < 0.01 vs. group 2; **p < 0.05 vs. group 2.

View larger version (13K): [in a new window]   Figure 2 Microvascular endothelium-dependent vasomotor response. Coronary flow velocity increase in response to intracoronary acetylcholine (ACh). Group 1 = patients with hypercholesterolemia adequately controlled; group 2 = patients with hypercholesterolemia inadequately controlled; group 3 = patients without hypercholesterolemia. *p < 0.05 vs. groups 1 and 3.