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Effects of interleukin-1 gene polymorphisms on the development of coronary artery disease associated with Chlamydia pneumoniae infection

Yukihiko Momiyama, MD^*, Reiko Hirano, PhD^*, Hiroaki Taniguchi, MD^*, Haruo Nakamura, MD and Fumitaka Ohsuzu, MD^*

^* First Department of Internal Medicine, National Defense Medical College, Saitama, Japan
Mitsukoshi Health and Welfare Foundation, Tokyo, Japan

View larger version (39K): [in a new window]   Figure 1 Interaction between Chlamydia pneumoniae (CP) seropositivity and interleukin (IL)-1 gene variants in coronary artery disease (CAD) and myocardial infarction (MI). Regarding CAD prevalence, a stepwise increase was seen depending on seropositivity and the variants. In contrast, MI prevalence was characteristically high in the group with combined seropositivity and variants. The IL-1 gene variants were defined as IL-1ß C/C genotype and/or IL-1 receptor antagonist 2- or 3-repeat allele.