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Prevention of intimal hyperplasia with recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in the porcine coronary artery balloon injury model

^a Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

View larger version (74K): [in a new window]   Figure 1 Photomicrographs of cross sections of porcine coronary arteries 28 days after injury (hematoxylin and eosin staining, 20x). (A) Representative light microscopy cross section of injured coronary artery from recombinant P-selectin glycoprotein ligand-immunoglobulin group, showing mild macrophage infiltration. (B) Representative light microscopy cross section of injured coronary artery from the placebo group, showing extensive macrophage infiltration.

View larger version (60K): [in a new window]   Figure 2 Photomicrographs of porcine coronary arteries 28 days after injury (Movat staining, 2.5x). (A) Representative light microscopy cross section of injured coronary artery from recombinant P-selectin glycoprotein ligand-immunoglobulin group, showing reduced neointimal hyperplasia with larger luminal area. (B) Representative light microscopy cross section of injured coronary artery from the placebo group, showing extensive neointimal hyperplasia with smaller luminal area. L = lumen. N = neointima, M = media.

View larger version (80K): [in a new window]   Figure 3 Immunohistochemical photomicrographs of porcine coronary arteries 28 days after injury (40x). Brown stain denotes presence of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and proliferating cell nuclear antigen (PCNA). (A) TNF-alpha immunostaining of injured coronary artery from recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig) group. (B) TNF-alpha immunostaining of injured coronary artery from the placebo group. (C) IL-1 beta immunostaining of injured coronary artery from rPSGL-Ig group. (D) IL-1 beta immunostaining of injured coronary artery from the placebo group. (E) PCNA immunostaining of injured coronary artery from rPSGL-Ig group. (F) PCNA immunostaining of injured coronary artery from the placebo group.