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Endothelium-dependent vasodilation is independent of the plasma L-arginine/ADMA ratio in men with stable angina

Lack of effect of oral l-arginine on endothelial function, oxidative stress and exercise performance

Hamish A. Walker, MRCP^*, Elaine McGing^*, Ian Fisher, BSc, Rainer H. Böger, MD, Stefanie M. Bode-Böger, MD, Graham Jackson, FRCP^*, James M. Ritter, FRCP and Philip J. Chowienczyk, FRCP

^* Cardiothoracic Centre, St. Thomas’ Hospital, London, United Kingdom
Department of Clinical Pharmacology, Centre for Cardiovascular Medicine and Biology, King’s College, London, St. Thomas’ Hospital, London, United Kingdom
Department of Pharmacology, University Hospital, Hamburg-Eppendorf, Hamburg, Germany
Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany

View larger version (16K): [in a new window]   Figure 1 Forearm blood flow responses to a) acetylcholine (ACh) at baseline and after placebo; b) ACh at baseline and after L-arginine; c) nitroprusside (NP) at baseline and after placebo; d) nitroprusside at baseline and after L-arginine. Responses to NP decreased significantly (p < 0.01) after L-arginine compared with placebo by two-way analysis of variance. Those to ACh tended to decrease but the difference did not reach significance (p < 0.1).