Geographical miss during catheter-based intracoronary beta-radiation: incidence and implications in the BRIE study
Georgios Sianos, MD*,
I. Patrick Kay, MBChB*,
Marco A. Costa, MD, PhD*,
Evelyn Regar, MD*,
Ken Kozuma, MD*,
Pim J. de Feyter, MD, PhD*,
Eric Boersma, PhD*,
Clemens Disco, MSc and
Patrick W. Serruys, MD, PhD, FESC, FACC*
* Department of Cardiology, Thoraxcenter, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands
Cardialysis BV, Rotterdam, Netherlands
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Figure 1 (Left) Isodose contour rate map and radiation source train. Isodose rate contour map at a depth of 1.89 mm (10 mGy/s contour intervals) as described by National Institute of Standards and Technology. This depth (1.89 mm) illustrates an isodose model resembling the radius of the coronary artery wall. The longitudinal dose falloff may be extrapolated from this graphic. The central part of the source train (26 mm) radiates approximately full dose constituting the effective irradiation length (EIRL). (Right) A diagram of an irradiated coronary artery and the anatomical and dose-based segment definition. EIRS = effective irradiated segment; INS = injured segment; IRS = irradiated segment; IRL = irradiation length; SB = side branch; VS = vessel segment.
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Figure 2 Difference in the restenosis rate in the proximal distal and both edges of the effective irradiated segment between geographical miss (GM) and noninjured edges. White bars = no GM; black bars = GM. CI = confidence interval; OR = odds ratio.
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Figure 3 Difference in edge restenosis between geographical miss (GM) edges associated with stent and balloon injury and noninjured edges. White bars = no GM; black bars = GM. CI = confidence interval; OR = odds ratio.
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