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Biphasic changes in left ventricular end-diastolic pressure during dynamic exercise in patients with nonobstructive hypertrophic cardiomyopathy

Yasushi Takeichi, MD, Mitsuhiro Yokota, MD, PhD, FACC^*,1, Mitsunori Iwase, MD, PhD, Hideo Izawa, MD, PhD, Takao Nishizawa, MD^*, Ryoji Ishiki, MD, PhD, Fuji Somura, MD, Kohzo Nagata, MD, PhD, Satoshi Isobe, MD and Akiko Noda, PhD

^* Cardiovascular Division, Department of Clinical Pathophysiology, Nagoya, Japan
First Department of Internal Medicine, Nagoya University, Graduate School of Medicine, Nagoya, Japan
Nagoya University School of Health Sciences, Nagoya, Japan

View larger version (106K): [in a new window]   Figure 1 Representative electrocardiograms, phonocardiograms, left ventricular pressure (LVP) tracings, and M-mode echocardiograms at baseline and during 50 W of exercise in a patient with hypertrophic cardiomyopathy.

View larger version (14K): [in a new window]   Figure 2 Relationships between heart rate and LVEDP (increment from baseline) during dynamic exercise in the control group (left) and group I (right). Numbers represent the number of patients analyzed. LVEDP = left ventricular end-diastolic pressure.

View larger version (31K): [in a new window]   Figure 3 Relationships between heart rate (HR) and LVEDP (increment from baseline) during dynamic exercise before (filled circle) and after (open circle) propranolol administration in group II patients. LVEDP = left ventricular end-diastolic pressure.

View larger version (17K): [in a new window]   Figure 4 Relationships between heart rate and the time constant of isovolumic relaxation (T1/2, normalized as the percentage of the value at baseline heart rate) during dynamic exercise in the control group (bottom), group I (upper), and group II (middle). Numbers represent the number of patients analyzed.