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Exercise-induced silent myocardial ischemia and coronary morbidity and mortality in middle-aged men

Jari A. Laukkanen, MD^*, Sudhir Kurl, MD^*, Timo A. Lakka, MD, PhD^*, Tomi-Pekka Tuomainen, MD^*, Rainer Rauramaa, MD, PhD, MSc, Riitta Salonen, MD, PhD^* , Jaakko Eränen, MD and Jukka T. Salonen, MD, PhD, MScPH^{* ||}

^* Research Institute of Public Health, University of Kuopio, Kuopio, Finland
Kuopio Research Institute of Exercise Medicine and the Departments of Clinical Physiology and Nuclear Medicine, University Hospital of Kuopio, Kuopio, Finland
Departments of Public Health and General Practice, University of Kuopio, Kuopio, Finland
Department of Medicine, University Hospital of Kuopio, Kuopio, Finland
^|| Inner Savo Health Centre, Suonejoki, Finland

View larger version (13K): [in a new window]   Figure 1 Cumulative hazards of coronary mortality in men with silent myocardial ischemia (high risk group) during exercise (A) and after exercise (B) versus all others (low risk group).

View larger version (33K): [in a new window]   Figure 2 The relative risks (RR) (95% confidence intervals) of acute coronary events (A) and coronary death (B) in men with silent myocardial ischemia during exercise, and the RRs of acute coronary events (C) and coronary death (D) in men with silent ischemia after exercise according to conventional risk factor levels. Men without myocardial ischemia were a reference group. Cut-off for systolic blood pressure was 132 mm Hg and for serum low density lipoprotein cholesterol 3.9 mmol/l. Adjusted for age, examination years, alcohol consumption, body-mass index, maximal oxygen uptake, diabetes, cigarette smoking, systolic blood pressure and serum low density lipoprotein and high density lipoprotein cholesterol, except the risk factor of interest.