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J Am Coll Cardiol, 2001; 38:64-71
© 2001 by the American College of Cardiology Foundation
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Prognostic value of ST segment depression in acute coronary syndromes: insights from PARAGON-A applied to GUSTO-IIb1

Padma Kaul, PhD*, Yuling Fu, MD*, Wei-Ching Chang, PhD*, Robert A. Harrington, MD{dagger}, Galen S. Wagner, MD{dagger}, Shaun G. Goodman, MD{ddagger}, Christopher B. Granger, MD{dagger}, David J. Moliterno, MD§, Frans Van de Werf, MD||, Robert M. Califf, MD{dagger}, Eric J. Topol, MD§, Paul W. Armstrong, MD* for the PARAGON-A and GUSTO-IIb Investigators

* University of Alberta, Edmonton, Alberta, Canada
{dagger} Duke Clinical Research Institute, Durham, North Carolina, USA
{ddagger} St. Michael’s Hospital, Toronto, Ontario, Canada
§ Cleveland Clinic Foundation, Cleveland, Ohio, USA
|| University Hospital Gasthuisberg, Leuven, Belgium



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Figure 1 Survival curves corresponding to the categories of no ST segment depression (dep), 1-mm ST segment depression and ≥2-mm ST segment depression in the PARAGON-A study (A) and GUSTO-IIb (B) studies. Log-rank tests were used to compare the survival curves. All curves were statistically significantly different at p < 0.05.

 


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Figure 2 Relative contribution of baseline risk factors in predicting one-year mortality (PARAGON-A data). CHF = congestive heart failure; COPD = chronic obstructive pulmonary disease; CVD = cerebrovascular disease; MI = myocardial infarction; PTCA = percutaneous transluminal coronary angioplasty; PVD = peripheral vascular disease.

 




 
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