Prognostic value of ST segment depression in acute coronary syndromes: insights from PARAGON-A applied to GUSTO-IIb1
Padma Kaul, PhD*,
Yuling Fu, MD*,
Wei-Ching Chang, PhD*,
Robert A. Harrington, MD ,
Galen S. Wagner, MD ,
Shaun G. Goodman, MD ,
Christopher B. Granger, MD ,
David J. Moliterno, MD ,
Frans Van de Werf, MD||,
Robert M. Califf, MD ,
Eric J. Topol, MD ,
Paul W. Armstrong, MD* for the PARAGON-A and GUSTO-IIb Investigators
* University of Alberta, Edmonton, Alberta, Canada
Duke Clinical Research Institute, Durham, North Carolina, USA
St. Michaels Hospital, Toronto, Ontario, Canada
Cleveland Clinic Foundation, Cleveland, Ohio, USA
|| University Hospital Gasthuisberg, Leuven, Belgium

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Figure 1 Survival curves corresponding to the categories of no ST segment depression (dep), 1-mm ST segment depression and 2-mm ST segment depression in the PARAGON-A study (A) and GUSTO-IIb (B) studies. Log-rank tests were used to compare the survival curves. All curves were statistically significantly different at p < 0.05.
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Figure 2 Relative contribution of baseline risk factors in predicting one-year mortality (PARAGON-A data). CHF = congestive heart failure; COPD = chronic obstructive pulmonary disease; CVD = cerebrovascular disease; MI = myocardial infarction; PTCA = percutaneous transluminal coronary angioplasty; PVD = peripheral vascular disease.
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