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Markedly reduced insulin-like growth factor-1 in the acute phase of myocardial infarction

Elena Conti, MD^*, Felicita Andreotti, MD, PhD^*, Alessandro Sciahbasi, MD^*, Patrizia Riccardi, PhD, Giampiero Marra, MD, Edoardo Menini, MD, Giovanni Ghirlanda, MD and Attilio Maseri, MD, FACC^*

^* Cardiology, Catholic University, Rome, Italy
Obstetrics and Gynecology, Catholic University, Rome, Italy
Division of Diabetology, Catholic University, Rome, Italy
Hormone Laboratory, Catholic University, Rome, Italy

View larger version (21K): [in a new window]   Figure 1 Serum concentrations of insulin-like growth factor-1 (IGF-1), diurnal growth hormone and fasting insulin in the first 12 patients (during the acute phase of infarction and at follow-up) and in controls (p values obtained by analysis of variance and Newman-Keuls test). Patients with acute myocardial infarction (shaded bars); patients after one year (black bars); controls (white bars).

View larger version (13K): [in a new window]   Figure 2 (A) Relation between insulin-like growth factor-1 (IGF-1) levels and time from symptom onset in patients with creatine kinase levels on admission <240 IU/l (open circles) or >240 IU/l (dark circles). (B) Relation between IGF-1 and C-reactive protein levels in patients with creatine kinase levels on admission <240 IU/l (open circles) or >240 IU/l (dark circles).

View larger version (27K): [in a new window]   Figure 3 Blood glucose concentrations following the intravenous bolus-injection of insulin in patients with acute myocardial infarction and in controls. The reduction in glycemia is slow in patients, but rapid in controls.