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Silent and clinically overt stroke in older Japanese subjects with white-coat and sustained hypertension

Kazuomi Kario, MD, PhD, FACC^* , Kazuyuki Shimada, MD, PhD^*, Joseph E. Schwartz, PhD, Takefumi Matsuo, MD, PhD, Satoshi Hoshide, MD^* and Thomas G. Pickering, MD, DPhil

^* Department of Cardiology, Jichi Medical School, Tochigi, Japan
The Zena and Michael A. Weiner Cardiovascular Center, Mount Sinai School of Medicine, New York, New York, USA
Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook, Stony Brook, New York, USA
Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Hyogo, Japan

View larger version (31K): [in a new window]   Figure 1 Prevalence of silent cerebral infarcts (SCI) detected by brain MRI. Multiple infarcts are defined as 2 infarcts per person. Overall p values for three groups comparisons are 0.006 for SCIs and 0.002 for multiple SCIs.

View larger version (28K): [in a new window]   Figure 2 Stroke and fatal stroke incidence. Overall p values for three groups comparisons are <0.0001 for stroke incidence and 0.036 for fatal stroke incidence.

View larger version (23K): [in a new window]   Figure 3 Stroke-free survival curves.

View larger version (31K): [in a new window]   Figure 4 Stroke incidence in the subjects with silent cerebral infarct (SCI) and in those without any SCI. Overall p value is <0.0001 for six group comparisons.