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Incidence of thrombotic occlusion and major adverse cardiac events between two and four weeks after coronary stent placement: analysis of 5,678 patients with a four-week ticlopidine regimen

Helmut Schühlen, MD, FESC^*, Adnan Kastrati, MD, FESC, J.ürgen Pache, MD, Josef Dirschinger, MD and Albert Schömig, MD

^* Medizinische Klinik, Klinikum rechts der Isar, Munich, Germany
Deutsches Herzzentrum, Technische Universität, Munich, Germany

View larger version (27K): [in a new window]   Figure 1 Cumulative event rates during the first 30 days after the procedure. Hatched box = early events (days 1 to 14); black box = late events (days 15 to 30). MI = myocardial infarction.

View larger version (16K): [in a new window]   Figure 2 Temporal distribution of all events. There were 112 events (2.0%) that occurred during the first 14 days and 30 events during days 15 to 30 (0.5%). Events per day are illustrated in a hierarchial order: hatched box = death; white box = nonfatal myocardial infarction; black box = occlusion.

View larger version (21K): [in a new window]   Figure 3 Significant and independent factors for stent failure within the first 30 days, displayed with their relative risk and 95% confidence interval (for continuous variables these were calculated for the first vs. the third quartile: age, 57.0 vs. 72.2 years; length of stented segment, 15 vs. 25 mm; residual stenosis, 5.5 vs. 10.5%). LV = left ventricular; TIMI = Thrombolysis In Myocardial Infarction.

View larger version (20K): [in a new window]   Figure 4 Significant and independent factors for stent failure differentiating the early period (i.e., the first 14 days) (A) from the late period (i.e., days 15 to 30) (B). Factors are displayed with their relative risk and 95% confidence interval (for continuous variables these were calculated for the first vs. the third quartile) (Fig. 3). LV = left ventricular; PTCA = percutaneous transluminal coronary angioplasty.

View larger version (17K): [in a new window]   Figure 5 Risk rates for late stent failure and their relation to significant risk factors (Fig. 4B). The numbers inside circles represent the rate of stent failure in this subgroup; the area of a circle represents the size of the subgroup (in relation to the circle on top, which comprises all analyzed procedures; n = 5,611). LV = left ventricular.