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Effects of low-dose aspirin on serum C-reactive protein and thromboxane B₂ concentrations: a placebo-controlled study using a highly sensitive C-reactive protein assay

Mark Feldman, MD^* , Ishwarlal Jialal, MD, Sridevi Devaraj, PhD and Byron Cryer, MD^*

^* Medical Service, Dallas Department of Veterans Affairs Medical Center, Dallas, Texas, USA
Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas, USA
Department of Pathology, University of Texas Southwestern Medical School, Dallas, Texas, USA

View larger version (45K): [in a new window]   Figure 1 Serum C-reactive protein (CRP) (expressed as a percentage of average baseline CRP levels) in each treatment group. Median changes are shown during treatment (day 28 and 31) and 14 days after treatment (day 45). Changes were not significant in any treatment group. ASA = aspirin; qd = every day; q3d = every third day.

View larger version (32K): [in a new window]   Figure 2 Serum thromboxane (Tx) (expressed as a percentage of average baseline Tx levels) in each treatment group. Median changes are shown during treatment (day 28 and 31) and 14 days after treatment (day 45). Changes were statistically significant (*p < 0.001) in groups 2, 3, 4 and 5, but not in group 1. ASA = aspirin; qd = every day; q3d = every third day.