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Angiotensin-converting enzyme inhibition enhances a subthreshold stimulus to elicit delayed preconditioning in pig myocardium

M. T. Jaberansari, MD^*, Gary F. Baxter, PhD, FIBiol, Cecile A. Muller, PhD, Sean E. Latouf, MD, E. Röth, MD, DSc^*, Lionel H. Opie, MD, DPhil, FACC and Derek M. Yellon, DSc, FACC

^* Department of Experimental Surgery, PTE, Pécs, Hungary
The Hatter Institute, UCL Medical School, London, United Kingdom
Cape Heart Centre, University of Cape Town, Cape Town, South Africa

View larger version (20K): [in a new window]   Figure 1 Experimental protocols. For details, see text. Perindopril 0.06 mg/kg i.v. was given in groups 4 and 5 (arrow).

View larger version (33K): [in a new window]   Figure 2 Infarct size. a: infarct-to-risk zone ratio; b: risk zone-to-LV ratio. *p < 0.01 versus group 1 (sham-operated control) (one-way analysis of variance).

View larger version (25K): [in a new window]   Figure 3 Incidence of ischemia and reperfusion-induced VF during the infarct protocol (day 2). Differences are not statistically significant.