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High-efficiency endovascular gene delivery via therapeutic ultrasound

Philippe G. Amabile, MD^*, Jacob M. Waugh, MD^*, Thomas N. Lewis, PhD, Christopher J. Elkins, PhD^*, Wolfgang Janas, RVT and Michael D. Dake, MD^*

^* Department of Cardiovascular and Interventional Radiology, Stanford University Medical Center, Stanford, California, USA
EKOS Corporation, Bothell, Washington, USA

View larger version (33K): [in a new window]   Figure 1 Ultrasound intensity field map for the EKOS catheter as measured in a hydrophone scanning tank. The peak intensity is located on the surface at the center of the ultrasound transducer and falls off away from that point. The field is axisymmetric around the catheter.

View larger version (21K): [in a new window]   Figure 2 Blue fluorescent protein (BFP) expression. Expression of BFP 7 days after delivery of buffer (PBS), plasmid expressing BFP (p/BFP), or adenovirus expressing BFP (Adv/BFP), each either with ultrasound treatment (black bars) or without (white bars). Values represent mean ± standard error.

View larger version (63K): [in a new window]   Figure 3 Representative photomicrographs. Photomicrographs (20x magnification) depicting blue fluorescent protein (BFP) expression as fluorescence through an FITC-HYQ filter with internal elastic lamina noted by yellow arrow after treatment with (A) saline alone, (B) saline with ultrasound (US), (C) pBFP alone, (D) pBFP with US, (E) AdBFP alone or (F) AdBFP with US. Scale = 20 µm.