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Intravenous atrial natriuretic peptide prevents left ventricular remodeling in patients with first anterior acute myocardial infarction

^a First Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Japan

View larger version (15K): [in a new window]   Figure 1 Changes in the ejection fraction (EF), left ventricular end-diastolic volume index (LVEDVI) and left ventricular end-systolic volume index (LVESVI) in the two randomized treatment groups from baseline to one month after. P(ANOVA) indicates the p value for time-group interaction. The white bars indicate the ANP group and the black bars the GTN group. *p < 0.001: difference between baseline and one-month values (within each group), p < 0.05, #p < 0.01.

View larger version (29K): [in a new window]   Figure 2 Effects of intravenous atrial natriuretic peptide (ANP) and nitroglycerin (GTN) on norepinephrine (NE), plasma active renin concentration (PARC), angiotensin II (Ang II), aldosterone (ALD) and endothelin-1 (ET-1). P(ANOVA) indicates the p value for time-group interaction. White bars indicate ANP group and black bars the GTN group. Baseline and 1 H indicate just before and after 1 H starting ANP or GTN. Before stop indicates just before stopping ANP or GTN. p < 0.05, #p < 0.01, *p < 0.001, p < 0.0001: difference between baseline and before stop values (within each group).