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J Am Coll Cardiol, 2001; 37:1726-1732
© 2001 by the American College of Cardiology Foundation
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Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia

Shmuel Fuchs, MD*, Richard Baffour, PhD*, Yi Fu Zhou, MD*, Matie Shou, MD*, Anthony Pierre, BSc*, Fermin O. Tio, MD{dagger}, Neil J. Weissman, MD*, Martin B. Leon, MD{ddagger}, Stephen E. Epstein, MD* and Ran Kornowski, MD*

* the Cardiovascular Research Institute, Washington, DC, USA
{dagger} Biomedical Research Foundation of South Texas Inc., San-Antonio, Texas, USA
{ddagger} Cardiovascular Research Foundation, Lenox Hill Hospital, New York, New York, USA



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  		Figure 1 (A) Effects of conditioned medium on PAEC proliferation. Pig aortic endothelial cells were seeded, in triplicate, in 96 well plates for one day; subsequently, the indicated volumes of conditioned medium from pooled samples or control medium were added (with comparable volume of PAEC medium removed). After four days, PAEC, cultured with conditioned medium or control medium, were harvested and counted. (B) Effects of conditioned medium on tritiated thymidine uptake by PAEC. After two days, 1 µCi tritiated thymidine was added to each well, and 48 h later, DNA in PAEC was harvested, and radioactivity was counted. (C and D) Changes in bone marrow cell conditioned medium of VEGF (C) and MCP-1 (D) concentrations at one to four weeks, assayed by ELISA. MCP-1 = macrophage chemoattractant protein-1; PAEC = pig aortic endothelial cells; VEGF = vascular endothelial growth factor.

 


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  		Figure 2 Myocardial injection site stained for CD-34 (left) and hematoxylin and eosin (right) at three days after transendocardial injection of ABM. Note strong staining for CD-34 in 4% to 6% of the cells.

 




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