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Response to flecainide infusion predicts long-term success of hybrid pharmacologic and ablation therapy in patients with atrial fibrillation

Giuseppe Stabile, MD^*, Antonio De Simone, MD^*, Pietro Turco, MD^*, Vincenzo La Rocca, MD^*, Pasquale Nocerino, MD^*, Costantino Astarita, MD, Francesco Maresca, MD, Carmine De Matteis, MD, Tommaso Di Napoli, MD, Eugenio Stabile, MD^|| and Dino Franco Vitale, MD^¶

^* Laboratorio di Elettrofisiologia, Casa di Cura "San Michele," Maddaloni (CE), Italy
Ospedale Civile di Sorrento, Sorrento (NA), Italy
Ospedale Civile di Arienzo, Arienzo (CE), Italy
Ospedale Civile di Polla, Polla (SA), Italy
^|| Università "Federico II" di Napoli, Napoli, Italy
^¶ Fondazione S. Maugeri I.R.C.C.S., Centro Medico di Telese, Telese (BN), Italy

View larger version (44K): [in a new window]   Figure 1 Surface intracardiac electrograms recorded before (A) and after (B) flecainide infusion, showing the transformation of atrial fibrillation into typical atrial flutter. I, III and V1 = electrocardiographic leads; CS = coronary sinus; HIS = His bundle; -d = distal; -p = proximal; T = tricuspid annulus, with T12 located at the low lateral atrium and T1516 at the high inter-atrial septum.

View larger version (17K): [in a new window]   Figure 2 Atrial fibrillation- and atrial flutter-free cumulative survival curves for the four patient groups (A–D).