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Bradykinin stimulates the release of tissue plasminogen activator in human coronary circulation: effects of angiotensin-converting enzyme inhibitors

^a First Department of Internal Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga, Japan

View larger version (19K): [in a new window]   Figure 1 The effects of bradykinin (0.2, 0.6, 2.0 µg/min), acetylcholine (ACh) (30 µg/min) and papaverine (PA) (12 mg) on the mean arterial pressure (upper panel), heart rate (middle panel) and percent change in coronary blood flow (lower panel) in the ACE inhibitor group (open box) and non-ACE inhibitor group (closed circle). *p < 0.05 versus baseline.

View larger version (14K): [in a new window]   Figure 2 The effects of bradykinin (0.2, 0.6, 2.0 µg/min), acetylcholine (ACh) (30 µg/min) and papaverine (PA) (12 mg) on tissue plasminogen activator (tPA) antigen in the aorta (Ao) and coronary sinus (CS) in the angiotensin-converting enzyme inhibitor group (open box) and the nonangiotensin-converting enzyme inhibitor group (closed circle). 2 min: 2 min after cessation of the infusion of bradykinin; 4 min: 4 min after cessation of the infusion of bradykinin. *p < 0.05 versus baseline.

View larger version (19K): [in a new window]   Figure 3 The effects of bradykinin (0.2, 0.6, 2.0 µg/min), acetylcholine (ACh) (30 µg/min) and papaverine (PA) (12 mg) on net tissue plasminogen activator (tPA) release in the angiotensin-converting enzyme inhibitor group (open box) and the nonangiotensin-converting enzyme inhibitor group (closed circle). *p < 0.05 versus baseline.

View larger version (13K): [in a new window]   Figure 4 The effects of bradykinin (0.2, 0.6, 2.0 µg/min), acetylcholine (ACh) (30 µg/min) and papaverine (PA) (12 mg) on plasminogen activator inhibitor (PAI-1) antigen in the aorta (Ao) and coronary sinus (CS) in the angiotensin-converting enzyme inhibitor group (open box) and the nonangiotensin-converting enzyme inhibitor group (closed circle).