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An insertion/deletion polymorphism in the _2b-adrenergic receptor gene is a novel genetic risk factor for acute coronary events

Amir Snapir, MD^*, Paula Heinonen, MD^*, Tomi-Pekka Tuomainen, MD, Pia Alhopuro, BM^*, Matti K. Karvonen, MD^*, Timo A. Lakka, MD, Kristiina Nyyssönen, PhD, Riitta Salonen, MD, Jussi Kauhanen, MD, Veli-Pekka Valkonen, BM, Ullamari Pesonen, PhD^*, Markku Koulu, MD^*, Mika Scheinin, MD^* and Jukka T. Salonen, MD

^* Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland
Research Institute of Public Health, University of Kuopio, Kuopio, Finland
Inner Savo Health Center, Suonenjoki, Finland

View larger version (53K): [in a new window]   Figure 1 Subject recruitment flowchart: the Kuopio Ischemic Heart Disease Risk Factor (KIHD) study. AMI = acute myocardial infarction; AR = adrenergic receptor; D = deletion; I = insertion.

View larger version (59K): [in a new window]   Figure 2 Electrophoretic separation of the polymerase chain reaction products. The insertion (I) and deletion (D) alleles were identified based on their different migration rates. bp = base pair.

View larger version (20K): [in a new window]   Figure 3 Event-free Kaplan-Meier survival function for acute coronary events. D = deletion; I = insertion.