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Attenuation of endothelin-1 induced vasoconstriction by 17ß estradiol is not sustained during long-term therapy in postmenopausal women with coronary heart disease

Pardeep S. Jhund, BSc^*, Nuala Dawson, MBChB, MRCP^*, Andrew P. Davie, BSc, MBChB, MRCP^*, Naveed Sattar, PhD, MBChB, MRCPath, John Norrie, BSc, MSc, Kevin P. J. O’Kane, BSc, MBChB, LLM, MRCP and John J. V. McMurray, BSc, MD, MBChB, FESC, FACC^*

^* Department of Cardiology, Western Infirmary, Glasgow, Scotland, UK
Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland, UK
Robertson Center for Biostatistics, University of Glasgow, Glasgow, Scotland, UK
Department of Medicine and Therapeutics, University of Glasgow, Glasgow, Scotland, UK

View larger version (17K): [in a new window]   Figure 1 Percentage change in forearm blood flow in response to infusion of 5 pmol/min of endothelin-1 (ET-1) for 60 min before randomization to either placebo or estradiol. Four measurements of forearm blood flow were made before infusion of ET-1 (–30, –15, –1 and 0 min). The last time point (0 min) was taken as baseline. The figure shows subsequent percent change in forearm blood flow during 60 min of ET-1 infusion in each treatment group (placebo or estradiol). There was no difference between the two treatments (p = 0.67).

View larger version (17K): [in a new window]   Figure 2 Percentage change in forearm blood flow in response to infusion of 5 pmol/min of endothelin-1 (ET-1) for 60 min after one month of randomized treatment. Compared with the placebo group, the estradiol group showed blunted vasoconstrictor response to ET-1 vasoconstriction in response to ET-1 (p = 0.041). Forearm blood flow is presented as in Figure 1.

View larger version (14K): [in a new window]   Figure 3 Percentage change in forearm blood flow in response to infusion of 5 pmol/min of endothelin-1 (ET-1) for 60 min after three months of randomized treatment. There was no difference between the two treatments (p = 0.65). Forearm blood flow is presented as in Figure 1.