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Antiplatelet effects of abciximab, tirofiban and eptifibatide in patients undergoing coronary stenting

^a Medizinische Klinik and Deutsches Herzzentrum, Technische Universität München, Munich, Germany. This study was supported in part by grants from MSD Sharp & Dohme, Haar, Germany, and from Accumetrics, San Diego, California

View larger version (21K): [in a new window]   Figure 1 Time course of the rate of platelet aggregation after stimulation with 4 µmol/liter of iso-TRAP, as assessed by RPFA during and after infusion of abciximab for 12 h (solid circles), tirofiban for 72 h (solid diamonds) or eptifibatide for 72 h (solid triangles). The plot shows the mean value ± SD. From 24 h onwards, the differences between the three agents were statistically significant (p < 0.001).

View larger version (20K): [in a new window]   Figure 2 Scatter plot of the rate of platelet aggregation after a 2-h infusion of abciximab (solid circles), tirofiban (solid diamonds) or eptifibatide (solid triangles), as assessed by rapid platelet-function assay (RPFA) with 4 µmol/liter of iso-thrombin receptor activating peptide or by turbidimetric aggregometry with 20 µmol/liter of adenosine diphosphate. The p values were calculated by one-way analysis of variance.

View larger version (20K): [in a new window]   Figure 3 Time course of the rate of platelet aggregation after stimulation with 20 µmol/liter of adenosine diphosphate, as assessed by turbidimetric aggregometry during and after infusion of abciximab for 12 h (solid circles), tirofiban for 72 h (solid diamonds) or eptifibatide for 72 h (solid triangles). The plot shows the mean value ± SD. From 24 h onwards, the differences between the three agents were statistically significant (p < 0.034).

View larger version (19K): [in a new window]   Figure 4 Time course of the rate of platelet aggregation after stimulation with 50 µmol/liter of thrombin receptor activating peptide, as assessed by turbidimetric aggregometry during and after infusion of abciximab for 12 h (solid circles), tirofiban for 72 h (solid diamonds) or eptifibatide for 72 h (solid triangles). The plot shows the mean value ± SD. At 24, 48 and 72 h, the differences between the three agents were statistically significant (p < 0.002).

View larger version (25K): [in a new window]   Figure 5 Time course of glycoprotein (GP) Ib immunofluorescence of monocytes as a measure of platelet-monocyte binding (left panel), and Mac-1 immunofluorescence of GP Ib-positive monocytes as a measure of Mac-1 expression on monocytes with adherent platelets (right panel) before and during infusion of abciximab (solid circles), tirofiban (solid diamonds) or eptifibatide (solid triangles). The plot shows the mean value ± SD.