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Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure

^a Cardiovascular Medicine, Alfred Hospital and Baker Medical Research Institute, Melbourne, Australia

View larger version (18K): [in a new window]   Figure 1 (A) Line graph represents the change in forearm blood flow (FBF) in response to intra-arterial (IA) clonidine, in healthy volunteers (n = 15). (B) Line graph represents the change in FBF in response to I/A clonidine, in patients with congestive heart failure (n = 10).

View larger version (18K): [in a new window]   Figure 2 (A) Line graph represents the forearm spillover (FSO) of norepinephrine (NE) in response to intra-arterial (I/A) clonidine, in healthy volunteers (n = 15). (B) Line graph represents the FSO of NE in response to I/A clonidine, in patients with congestive heart failure (n = 10) (p = NS).