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Effects of intravenous brain natriuretic peptide on regional sympathetic activity in patients with chronic heart failure as compared with healthy control subjects

Hans P. Brunner-La Rocca, MD^*,1, David M. Kaye, MBBS, PhD, FRACP, FACC^*,2, Robyn L. Woods, PhD, Jacqueline Hastings, PhD^* and Murray D. Esler, MBBS, PhD, FRACP^*

^* Alfred and Baker Medical Unit, Baker Medical Research Institute, Alfred Hospital, Melbourne, Australia
Howard Florey Institute, University of Melbourne, Parkville, Australia

View larger version (33K): [in a new window]   Figure 1 Hemodynamic data in patients with CHF as compared with healthy subjects before (B) and after (BNP) infusion of BNP (15 ng/kg per min). *p < 0.05 between groups; p < 0.05 after BNP infusion versus baseline; p < 0.05 response to BNP between different groups. BNP = brain, or b-type, natriuretic peptide; CHF = congestive heart failure; CI = cardiac index; DP = diastolic pressure; HR = heart rate; PAP = pulmonary artery pressure; PCWP = pulmonary capillary wedge pressure; RA = right atrial (pressure).

View larger version (25K): [in a new window]   Figure 2 Whole-body (top panel), cardiac (middle panel) and renal (bottom panel) NE SP in patients with CHF as compared with healthy subjects before (B) and after the lower (BNP1) and higher (BNP2) BNP dose. *p < 0.05 between groups; p < 0.05 after BNP infusion versus baseline; p < 0.05 response to BNP between different groups. BNP = brain, or b-type, natriuretic peptide; CHF = congestive heart failure; NE = norepinephrine; SP = spillover.

View larger version (25K): [in a new window]   Figure 3 Scatter plots of changes in cardiac (top panel; lower BNP dose), whole-body (middle panel; lower BNP dose) and renal (bottom panel; higher BNP dose) NESP in relation to baseline levels in both groups. The "r" values are rank correlations. BNP = brain, or b-type, natriuretic peptide; CHF = congestive heart failure; NESP= norepinephrine spillover.