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Figure 1 Progression of cell death versus time after left circumflex coronary occlusion. Necrosis occurs first in the subendocardial myocardium. With long occlusions, a wavefront of cell death moves from the subendocardial zone across the wall to involve progressively more of the transmural thickness of the ischemic zone. Typically a large zone of subepicardial myocardium in the ischemic bed is salvageable by early reperfusion. In contrast, the lateral margins in the subendocardial region of the infarct are established as early as 40 min after occlusion ([Reprinted with permission] Fig. 6 from reference 4). AP = anterior papillary; PP = posterior papillary.
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