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Alterations in potassium channel gene expression in atria of patients with persistent and paroxysmal atrial fibrillation: differential regulation of protein and mRNA levels for K⁺ channels

Bianca J. J. M. Brundel, MSc^* , Isabelle C. Van Gelder, MD^*, Robert H. Henning, MD, Anton E. Tuinenburg, MD^*, Mirian Wietses, Jan G. Grandjean, MD, Arthur A. M. Wilde, MD, Wiek H. Van Gilst, PhD and Harry J. G. M. Crijns, MD^*

^* Department of Cardiology, Thoraxcenter University Hospital Groningen, Groningen, The Netherlands
Department of Clinical Pharmacology, Thoraxcenter University Hospital Groningen, Groningen, The Netherlands
Department of Thoracic Surgery, Thoraxcenter University Hospital Groningen, Groningen, The Netherlands
Department of Cardiology, University of Amsterdam, Utrecht, The Netherlands

View larger version (23K): [in a new window]   Figure 1 The top of each panel shows a typical Western blot analysis of 10 µg of protein homogenates of three patients in sinus rhythm (SR), three patients with persistent (chronic) atrial fibrillation (CAF) and three patients with paroxysmal AF (PAF). The immunoblots were done for anti-Kv4.3 (A), anti-Kv1.5 (B), and anti-Kir3.1 (C) with glyceraldehyde-3-phosphate dehydrogenase (37 kD) as an internal control. All data are presented as density units/density units. Values are mean ± SEM.

View larger version (15K): [in a new window]   Figure 2 Correlation between the mean protein expression of Kv4.3 (triangle, r = 0.67, p > 0.05), Kv1.5 (circle, r = 0.97, p = 0.02) and Kir3.1 (square, r = 0.56, p > 0.05) in patients with paroxysmal atrial fibrillation and the duration of sinus rhythm before surgery.