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Aldosterone synthase (CYP11B2) –344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension

Christian Delles, MD^*, Jeanette Erdmann, PhD, Johannes Jacobi, MD^*, Karl F. Hilgers, MD^*, Eckart Fleck, MD, Vera Regitz-Zagrosek, MD and Roland E. Schmieder, MD, FACC^*

^* Department of Medicine/Nephrology, University of Erlangen, Nürnberg, Germany
Department of Medicine/Cardiology, Charité, Campus Virchow-Klinikum, Humboldt University and Deutsches Herzzentrum, Berlin, Germany

View larger version (14K): [in a new window]   Figure 1 Cardiac structure in hypertensive subjects stratified according to the aldosterone synthase promoter –344 C/T polymorphism (filled circles, TT; filled squares, CT; filled triangles, CC). An asterisk (*) indicates significant differences across the respective genotypes (p < 0.05).