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Hyperinsulinemia and hemostatic abnormalities are associated with silent lacunar cerebral infarcts in elderly hypertensive subjects

Kazuomi Kario, MD, PhD, FACC^* , Takefumi Matsuo, MD, PhD, Hiroko Kobayashi, BA, Satoshi Hoshide, MD^* and Kazuyuki Shimada, MD, PhD^*

^* Department of Cardiology, Jichi Medical School, Tochigi, Japan
Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Hyogo, Japan
Integrative and Behavioral Cardiology Program, Zena and Michael A. Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York, USA

View larger version (113K): [in a new window]   Figure 1 Brain MRI findings (T2-weighted images) of silent multiple lacunar infarcts. The top images show lacunar infarcts (arrows) in the basal ganglia, and the lower images show those infarcts (arrows) in the deep white matter. Cerebral infarcts were defined exclusively as a low signal intensity area (3 to 15 mm in size), depicted on T1-weighted images, that was also visible as a hyperintense lesion on T2-weighted images. MRI = magnetic resonance imaging.