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Radiation therapy impairs endothelium-dependent vasodilation in humans

Joshua A. Beckman, MD, FACC^*, Avni Thakore, MS^*, Barbara H. Kalinowski, RN, MSN, Jay R. Harris, MD and Mark A. Creager, MD, FACC^*

^* Vascular Medicine Section, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Department of Radiation Oncology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

View larger version (14K): [in a new window]   Figure 1 Effect of radiation therapy on flow-mediated vasodilation. The individual and mean percent increase in axillary artery size 1 min after cuff release compared with baseline is illustrated. Error bars represent standard error. Flow-mediated vasodilation was significantly impaired in irradiated arteries compared with nonirradiated arteries and arteries in control subjects (p < 0.001).

View larger version (14K): [in a new window]   Figure 2 Effect of radiation therapy on nitroglycerin-mediated vasodilation. The individual and mean percent increase in axillary artery size after nitroglycerin administration is shown. Error bars represent standard error. Nitroglycerin-mediated vasodilation was significantly greater in irradiated arteries compared with nonirradiated arteries and arteries in control subjects (p < 0.05).

View larger version (13K): [in a new window]   Figure 3 Inter-arm variation between healthy control subjects. The individual and mean flow-mediated and nitroglycerin-mediated vasodilation in the right and left arms of the control subjects. Error bars represent standard error. There is no significant difference between arms for either flow-mediated or nitroglycerin-mediated vasodilation.