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Prediction of mortality using dobutamine echocardiography

Thomas H. Marwick, MBBS, PhD, FACC^*, Colin Case, MS^*, Stephen Sawada, MD, FACC, Curtis Rimmerman, MD, FACC, Patricia Brenneman, BA, Roxanne Kovacs, MSN, Leanne Short, BS^* and Michael Lauer, MD, FACC

^* Department of Medicine, University of Queensland, Queensland, Australia
Cleveland Clinic Foundation, Cleveland, Ohio, USA
Indiana University, Indianapolis, Indiana, USA

View larger version (23K): [in a new window]   Figure 1 Kaplan-Meyer survival curves for the prediction of total (A) and cardiac (B) mortality based on results of dobutamine echocardiography. The outcome of patients with a normal scan was significantly different from those with scar, ischemia or a mixed pattern.

View larger version (17K): [in a new window]   Figure 2 Survival curves derived from the Cox model showing the relation of extent of abnormal function at peak stress to outcome. The outcome of patients with a normal scan was significantly different from those with functional abnormalities of increasing severity (p < 0.0001).

View larger version (20K): [in a new window]   Figure 3 Incremental value (expressed on y axis as model chi-square) of dobutamine stress echocardiography results to clinical characteristics and resting LV function for prediction of cardiac outcome. See text for components of models. LV = left ventricular.

View larger version (15K): [in a new window]   Figure 4 Incremental value (expressed on y axis as model chi-square) of dobutamine stress echocardiography results to clinical characteristics and coronary angiography for prediction of cardiac outcome. Multivariate analysis of independent predictors of outcome in 1,073 patients who underwent dobutamine echocardiography and coronary angiography. DbE = dobutamine echocardiography.