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J Am Coll Cardiol, 2001; 37:735-740
© 2001 by the American College of Cardiology Foundation
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Estradiol supplementation suppresses hyperventilation-induced attacks in postmenopausal women with variant angina

Hiroaki Kawano, MDa, Takeshi Motoyama, MDa, Nobutaka Hirai, MDa, Kiyotaka Kugiyama, MDa, Hisao Ogawa, MDa and Hirofumi Yasue, MDa

a Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan



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Figure 1 Schematic representation of the experimental protocol.

 


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Figure 2 A representative case (case 1). At baseline (day 1), the hyperventilation (HV) test induced anginal attacks with ST segment elevation in leads II, III and aVF and depression in leads I and aVL (A), but not after estradiol (E2) supplementation (day 3) (B). After placebo administration (day 5), the HV test again induced anginal attacks with ST segment elevation in leads II, III and aVF and depression in leads I and aVL (C).

 




 
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