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Estradiol supplementation suppresses hyperventilation-induced attacks in postmenopausal women with variant angina

^a Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan

View larger version (19K): [in a new window]   Figure 1 Schematic representation of the experimental protocol.

View larger version (27K): [in a new window]   Figure 2 A representative case (case 1). At baseline (day 1), the hyperventilation (HV) test induced anginal attacks with ST segment elevation in leads II, III and aVF and depression in leads I and aVL (A), but not after estradiol (E2) supplementation (day 3) (B). After placebo administration (day 5), the HV test again induced anginal attacks with ST segment elevation in leads II, III and aVF and depression in leads I and aVL (C).