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Estrogen-induced small low density lipoprotein particles may be atherogenic in postmenopausal women

^a Department of Obstetrics and Gynecology, Kochi Medical School, Kochi, Japan

View larger version (12K): [in a new window]   Figure 1 (A) Relationship between plasma triglyceride concentrations and LDL diameter. Open circles and solid line indicate pretreatment. Closed circles and dashed line indicate posttreatment. Pretreatment: y = –0.014x + 27.47, r = –0.91, p < 0.001; posttreatment: y = –0.012x + 26.94, r = –0.86, p < 0.001. (B) Relationship between estrogen-induced changes in plasma triglyceride concentrations and changes in LDL diameter (y = –0.011x – 0.33, r = –0.55, p < 0.005). LDL = low density lipoprotein.

View larger version (12K): [in a new window]   Figure 2 (A) Relationship between LDL diameter and the concentration of LDL-derived TBARS. Open circles and solid line indicate pretreatment. Closed circles and dashed line indicate posttreatment. Pretreatment: y = –6.22x + 180.63, r = –0.70, p < 0.001; posttreatment: y = –7.97x + 222.43, r = –0.64, p < 0.001. (B) Relationship between estrogen-induced changes in LDL diameter and changes in the concentration of LDL-derived TBARS (y = –4.97x –1.99, r = –0.49, p < 0.005). LDL = low density lipoprotein; TBARS = thiobarbituric acid-reactive substances.

View larger version (13K): [in a new window]   Figure 3 Relationship between estrogen-induced changes in plasma triglyceride concentration and changes in the concentration of LDL-derived TBARS (y = 0.11x –1.66, r = 0.66, p < 0.001). LDL = low density lipoprotein; TBARS = thiobarbituric acid-reactive substances.