Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy
Tomoaki Ohtsuka, MDa,
Mareomi Hamada, MD, FACCa,
Go Hiasa, MDa,
Osamu Sasaki, MDa,
Makoto Suzuki, MDa,
Yuji Hara, MDa,
Yuji Shigematsu, MDa and
Kunio Hiwada, MDa
a Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan

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Figure 1 Graphs showing the serum levels of IL-10 (A), TNF-alpha (B), sTNF-R1 (C) and sTNF-R2 (D) in 10 age-matched control subjects and in 32 patients with DCM at baseline. *p < 0.05. **p < 0.005 vs. control subjects.
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Figure 2 Scatterplots showing a correlation between IL-10 and TNF-alpha in 32 patients with DCM.
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Figure 3 Scatterplots showing correlations (A) between sTNF-R2 and left ventricular end-diastolic dimension (LVEDD) and (B) between plasma epinephrine levels and the TNF-alpha/IL-10 ratio in 32 patients with DCM.
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Figure 4 Comparisons of serum levels of IL-10 (A), TNF-alpha (B), sTNF-R1 (C) and sTNF-R2 (D) at baseline and 12 weeks after the initiation of beta-blocker therapy in 32 patients with DCM. *p < 0.005. **p < 0.001 vs. control subjects.
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