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Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy

^a Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan

View larger version (28K): [in a new window]   Figure 1 Graphs showing the serum levels of IL-10 (A), TNF-alpha (B), sTNF-R1 (C) and sTNF-R2 (D) in 10 age-matched control subjects and in 32 patients with DCM at baseline. *p < 0.05. **p < 0.005 vs. control subjects.

View larger version (22K): [in a new window]   Figure 2 Scatterplots showing a correlation between IL-10 and TNF-alpha in 32 patients with DCM.

View larger version (20K): [in a new window]   Figure 3 Scatterplots showing correlations (A) between sTNF-R2 and left ventricular end-diastolic dimension (LVEDD) and (B) between plasma epinephrine levels and the TNF-alpha/IL-10 ratio in 32 patients with DCM.

View larger version (44K): [in a new window]   Figure 4 Comparisons of serum levels of IL-10 (A), TNF-alpha (B), sTNF-R1 (C) and sTNF-R2 (D) at baseline and 12 weeks after the initiation of beta-blocker therapy in 32 patients with DCM. *p < 0.005. **p < 0.001 vs. control subjects.