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J Am Coll Cardiol, 2001; 37:398-406
© 2001 by the American College of Cardiology Foundation
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Modulation of alveolar-capillary sodium handling as a mechanism of protection of gas transfer by enalapril, and not by losartan, in chronic heart failure

Marco Guazzi, MD, PhD, FACCa, Piergiuseppe Agostoni, MD, PhDa and Maurizio D. Guazzi, MD, PhDa

a Istituto di Cardiologia dell’Università degli Studi, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Centro Cardiologico, I.R.C.C.S., Milano, Italy



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  		Figure 1 Study design.

 


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  		Figure 2 Pulmonary diffusion capacity for carbon monoxide (DCO), alveolar-capillary membrane-diffusing capacity (DM), pulmonary capillary blood volume (Vc'), mean wedge pulmonary pressure () and mean right atrial pressure () in group 1 patients before and after 150-ml and 750-ml saline infusions in the absence (open circles) and presence (solid circles) of enalapril in the therapeutic regimen. *p < 0.01 vs. baseline. {Delta}p < 0.01 vs. corresponding value before enalapril treatment.

 


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  		Figure 3 Respiratory average percent variations in group 1 patients from before to immediately after 150-ml and 750-ml saline infusions in the control condition (open columns) and after enalapril treatment (solid bars). *p < 0.01 vs. control condition. Abbreviations as in Figure 2.

 


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  		Figure 4 Pulmonary diffusion capacity for carbon monoxide (DCO), alveolar-capillary membrane-diffusing capacity (DM), pulmonary capillary blood volume (Vc'), mean wedge pulmonary pressure () and mean right atrial pressure () in group 1 patients before and after 150-ml and 750-ml saline infusions in the absence (open circles) and presence (solid triangles) of losartan in the therapeutic regimen. *p < 0.01 vs. baseline.

 


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  		Figure 5 Pulmonary diffusion capacity for carbon monoxide (DCO), alveolar-capillary membrane-diffusing capacity (DM) and pulmonary capillary blood volume (Vc') before and after 150-ml and 750-ml saline infusions in the control condition (open circles), with enalapril alone (solid circles) and after combining aspirin with enalapril (solid squares). *p < 0.05 vs. baseline. {Delta}p < 0.05 vs. corresponding control value. #p < 0.05 vs. corresponding enalapril value.

 




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