Modulation of alveolar-capillary sodium handling as a mechanism of protection of gas transfer by enalapril, and not by losartan, in chronic heart failure
Marco Guazzi, MD, PhD, FACCa,
Piergiuseppe Agostoni, MD, PhDa and
Maurizio D. Guazzi, MD, PhDa
a Istituto di Cardiologia dell’Università degli Studi, Centro di Studio per le Ricerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Centro Cardiologico, I.R.C.C.S., Milano, Italy
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Figure 3 Respiratory average percent variations in group 1 patients from before to immediately after 150-ml and 750-ml saline infusions in the control condition (open columns) and after enalapril treatment (solid bars). *p < 0.01 vs. control condition. Abbreviations as in Figure 2.
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Figure 5 Pulmonary diffusion capacity for carbon monoxide (DCO), alveolar-capillary membrane-diffusing capacity (DM) and pulmonary capillary blood volume (Vc') before and after 150-ml and 750-ml saline infusions in the control condition (open circles), with enalapril alone (solid circles) and after combining aspirin with enalapril (solid squares). *p < 0.05 vs. baseline.  p < 0.05 vs. corresponding control value. #p < 0.05 vs. corresponding enalapril value.
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) and mean right atrial pressure (
) in group 1 patients before and after 150-ml and 750-ml saline infusions in the absence (open circles) and presence (solid circles) of enalapril in the therapeutic regimen. *p < 0.01 vs. baseline. 