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Renin angiotensin system-dependent hypertrophy as a contributor to heart failure in hypertensive rats: different characteristics from renin angiotensin system-independent hypertrophy

Yasushi Sakata, MD^*, Tohru Masuyama, MD, PhD, FACC^*, Kazuhiro Yamamoto, MD, PhD, FACC^*, Reiko Doi, MD, PhD^*, Toshiaki Mano, MD, PhD^*, Tsunehiko Kuzuya, MD, PhD^*, Takeshi Miwa, PhD, Hiroshi Takeda, MD, PhD and Masatsugu Hori, MD, PhD, FACC^*

^* Department of Internal Medicine and Therapeutics, Osaka University, Suita, Japan
Genome Information Research Center, Osaka University, Suita, Japan
Department of Medical Information Science, Osaka University Graduate School of Medicine, Suita, Japan

View larger version (15K): [in a new window]   Figure 1 Serial changes in LV mass index in control, CAND(–) and CAND(+) rats. p value of analysis of variance main effects: group, <0.0001; time course, <0.0001. p value of analysis of variance interaction, <0.0001. **p < 0.01 versus control group; p < 0.01 versus CAND(–) group at same time point. Values are means ± SEM. LV = left ventricular.

View larger version (21K): [in a new window]   Figure 2 Postmortem LVMI at 13 and 19 weeks in control, CAND(–) and CAND(+) rats. **p < 0.01 vs. control group; p < 0.01 vs. CAND(–) group. p value of analysis of variance main effects: 13 weeks: <0.0001; 19 weeks: <0.0001. Values are means ± SEM. LVMI = left ventricular mass index.

View larger version (137K): [in a new window]   Figure 3 Photomicrographs of Azan Mallory staining of left ventricle in a CAND(–) rat (left panel) and a CAND(+) rat (right panel) (x40). Interstitial and perivascular fibrosis is evident only in CAND(–) rats.

View larger version (22K): [in a new window]   Figure 4 The mRNA levels of ACE, AT1a receptor at 13 and 19 weeks old. Each mRNA level was corrected for an mRNA level of glyceraldehyde-3-phosphate-dehydrogenase and was then normalized to a mean value of age-matched control group, respectively. **p < 0.01 versus control group; p < 0.01 versus CAND(–) group. Values are means ± SEM. Hatched bar= control; solid bar= CAND(–); open bar= CAND(+). ACE = angiotensin-converting enzyme; mRNA = messenger RNA.

View larger version (31K): [in a new window]   Figure 5 The mRNA levels of ppET-1, ECE, ET type A receptor and ET type B receptor at 13 and 19 weeks. Each mRNA level was corrected for an mRNA level of glyceraldehyde-3-phosphate-dehydrogenase and was then normalized to a mean value of the age-matched control group, respectively. *p < 0.05; **p < 0.01 versus control group; p < 0.05; p < 0.01 versus CAND(–) group. Values are means ± SEM. ECE = endothelin-converting enzyme; ET = endothelin; ppET-1 = prepro endothelin-1.