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Sildenafil citrate (Viagra) does not exacerbate myocardial ischemia in canine models of coronary artery stenosis

^a Heart Institute, Good Samaritan Hospital, and Department of Medicine, Section of Cardiology, University of Southern California, Los Angeles, California, USA

View larger version (20K): [in a new window]   Figure 1 Results (group means ± SEM) for Protocol 1: coronary artery stenosis stable coronary flow. (A) % Flow-time area and (B) Regional myocardial blood flow (RMBF) in endocardial (Endo) and epicardial (Epi) segments of the stenotic left anterior descending coronary artery bed for control and sildenafil-treated dogs. Black bars indicate controls; white bars indicate sildenafil. PreTreat = data obtained during the initial hour before randomization and treatment.

View larger version (19K): [in a new window]   Figure 2 Results (group means ± SEM) for Protocol 2: coronary artery injury + stenosis cyclic variations in coronary flow (CFVs). (A) In vitro platelet aggregation (i.e., maximum impedance in response to 10 µg collagen), and (B) % Flow-time area for control and sildenafil-treated dogs. Black bars indicate controls; white bars indicate sildenafil. PreTreat = data obtained during the initial hour before randomization and treatment. * p < 0.05 vs. control; p < 0.05 vs. PreTreat.

View larger version (46K): [in a new window]   Figure 3 Whole-blood impedance aggregometry: Protocol 3. (A) Original recordings of in vitro platelet aggregation (i.e., increase in impedance) in blood aliquots exogenously treated with sildenafil, the adenosine A2 agonist CGS 21680, sildenafil + CGS 21680, and no drug (control). Arrows indicate addition of collagen (10 µg); bar = 2 min. (B) % Change in impedance (mean ± SEM) seen in CGS 21680-treated aliquots versus paired "no drug" samples. Data were obtained at baseline and after dose 2 in two vehicle-treated and two sildenafil-treated dogs. Black bars indicate controls; white bars indicate sildenafil.