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Quantitative assessment of myocardial perfusion during graded coronary stenosis by real-time myocardial contrast echo refilling curves

^a Cardiovascular Division, University of California at San Diego, San Diego, California, USA

View larger version (44K): [in a new window]   Figure 1 Ratio of LAD/circumflex (LCx) myocardial blood flow (MBF) and regional LV wall thickening of risk area without stenosis, at three graded (mild, moderate, and severe) non-flow-limiting coronary stenoses (NFLS), flow-limiting coronary stenosis (FLS), and LAD occlusion during adenosine vasodilation. *p < 0.05, **p < 0.0001 versus no stenosis.

View larger version (117K): [in a new window]   Figure 2 Consecutive end-systolic images after FLASH transmission during vasodilation without stenosis (same animal as Figs. 3–4).

View larger version (112K): [in a new window]   Figure 3 Same as Figure 2 with moderate NFLS.

View larger version (113K): [in a new window]   Figure 4 Same as Figure 2 with severe NFLS.

View larger version (96K): [in a new window]   Figure 5 Myocardial signal-intensity-vs.-time plots and the curve fitting using a one-exponential function in the risk area at each level of stenosis in the same animal as Figure 2. b = the rate of intensity rise; Peak = the maximum intensity obtained at the end of the curve; FLS = flow-limiting stenosis; NFLS = non-flow-limiting stenosis.

View larger version (28K): [in a new window]   Figure 6 Averaged values of myocardial signal intensity in the risk area derived from curve fitting at each grade in all experiments. FLS = flow limiting stenosis; NFLS = non-flow-limiting stenosis.

View larger version (24K): [in a new window]   Figure 7 Comparison of peak signal intensity (SI), the rate of SI rise (b), and the product of peak SI and b at each level of stenosis. *p < 0.0001, p < 0.001 vs. no stenosis. FLS = flow-limiting stenosis; NFLS = non-flow-limiting stenosis.